NFL Football Picks sets up two primetime NFL matchups, starting with Drew Brees and the New Orleans Saints taking on Peyton Manning and the Denver Broncos on Sunday Night Football at Sports Authority Field at Mile High (8:20 pm ET, NBC).
NFL Odds at Legends have the Broncos as a 7-point favorite and the over/under total at 55.
Get the winning NFL picks for this game from NFL Handicapping expert Scott Matthews of SM Picks, who has been making money for his clients for 25 years.
Last weekend, the Saints (2-4 SU, 3-3 ATS) beat division rival Tampa Bay Buccaneers 35-28 and covered as a 1.5-point road favorite. Denver (3-3 straight up and against the point spread) had a bye last week after beating the San Diego Chargers 35-24 on Monday Night Football, cashing as a 1-point road underdog.
NFL Betting trends show that Denver has beaten New Orleans four times in the past six meetings. This is the first clash between the teams since 2008, when the Broncos won 34-32 but failed to cover as a 5.5-point home favorite.
A night later, the San Francisco 49ers and the Arizona Cardinals meet in an NFC West battle on Monday Night Football at the University of Phoenix Stadium (8:30 pm ET, ESPN).
NFL Betting Odds have the 49ers as a 7-point favorite and the over/under total at 38.
San Francisco has won five of the past six meetings, but the teams split their two meetings last season. Arizona won 21-19 on Dec. 12 and cashed as a 3.5-point home underdog, and San Francisco won 23-7 on Nov. 20, cashing as a 10-point home fave.
Last week, the 49ers beat the Seattle Seahawks 13-6 on Thursday Night Football but failed to as a 7.5-point home favorite. Arizona lost 21-14 to the Minnesota Vikings last Sunday, with the score a push as the Cardinals were 7-point road underdogs.