NFL Betting Picks at SM Picks previews this week’s Thursday Night Football matchup, which has the NFC West division rivals Arizona Cardinals and St. Louis Rams battling at the Edward Jones Dome (5 pm ET, NFL Network).
Arizona is a 2-point, -125 moneyline favorite while the Rams are a +105 underdog, and the over/under total is at 39 in NFL Odds.
Get the winning Football Picks prediction from expert football handicapper Scott Matthews of SM Picks, who’s been making profits for his clients for 25 years.
Head to head, the Cardinals are 9-1 straight up and 7-3 against the spread in the past 10 meetings, and 4-1 ATS in the past five. The total has gone under in 7 of the last 8 meetings.
The Cardinals won both games in the season series last year, winning 23-20 on Nov. 27 and covering as a 2.5-point road underdog, and winning 19-13 in the first meeting, cashing as a 1-point home favorite.
Arizona (4-0 SU, 3-1 ATS) beat the Miami Dolphins 24-21 on Sunday but failed to cover as a 4-point home favorite. St. Louis (2-2 SU, 3-1 ATS) beat the Seattle Seahawks 19-13 on Sunday and cashed as a 2.5-point home underdog.
NFL Betting trends show that Arizona is 5-0 SU in its last 5 games overall but is a pitiful 3-13 SU in its last 16 games on the road. Over/under bettors should note that the total has gone under in 4 of Arizona's last 6 games overall, and in 4 of its last 5 games on the road.
While the Cardinals are off to a decent start this season, they are just 2-9 SU in their last 11 games (both wins this season), 3-7 straight up in their last 10 games at home, and 6-14-1 against the spread in their last 21 games overall.